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proteomic results  (Bruker Corporation)


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    Bruker Corporation proteomic results
    Schematic representation of experimental model (A) and analysis workflow (B). Wistar Han rats were bilaterally injected with 6-OHDA (3 µg / 3 µl) into the medial forebrain bundle to induce selective degeneration of dopaminergic neurons and infused for 7 days with fluorocitrate (FC, 2 nmol/day, osmotic minipumps) to induce astrocyte death in the substantia nigra. Substantia nigra tissue was dissected and dissociated into a cell suspension, stained with microglia or astrocyte-specific fluorescent antibodies, and fractionated into astrocytic or microglial clean fractions. Cells were lysed and proteins processed for <t>proteomic</t> analysis. Brain outline based on Paxinos and Watson`s atlas. Created in BioRender. Kuter, K. (2026) https://BioRender.com/1cxstxv .
    Proteomic Results, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 99/100, based on 3891 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/proteomic+results/pmc12877848-70-3-8?v=Bruker+Corporation
    Average 99 stars, based on 3891 article reviews
    proteomic results - by Bioz Stars, 2026-08
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    1) Product Images from "Glial cell-specific proteomic data from the substantia nigra of a rat 6-OHDA and fluorocitrate model of astrocyte death and microglial activation"

    Article Title: Glial cell-specific proteomic data from the substantia nigra of a rat 6-OHDA and fluorocitrate model of astrocyte death and microglial activation

    Journal: Data in Brief

    doi: 10.1016/j.dib.2026.112473

    Schematic representation of experimental model (A) and analysis workflow (B). Wistar Han rats were bilaterally injected with 6-OHDA (3 µg / 3 µl) into the medial forebrain bundle to induce selective degeneration of dopaminergic neurons and infused for 7 days with fluorocitrate (FC, 2 nmol/day, osmotic minipumps) to induce astrocyte death in the substantia nigra. Substantia nigra tissue was dissected and dissociated into a cell suspension, stained with microglia or astrocyte-specific fluorescent antibodies, and fractionated into astrocytic or microglial clean fractions. Cells were lysed and proteins processed for proteomic analysis. Brain outline based on Paxinos and Watson`s atlas. Created in BioRender. Kuter, K. (2026) https://BioRender.com/1cxstxv .
    Figure Legend Snippet: Schematic representation of experimental model (A) and analysis workflow (B). Wistar Han rats were bilaterally injected with 6-OHDA (3 µg / 3 µl) into the medial forebrain bundle to induce selective degeneration of dopaminergic neurons and infused for 7 days with fluorocitrate (FC, 2 nmol/day, osmotic minipumps) to induce astrocyte death in the substantia nigra. Substantia nigra tissue was dissected and dissociated into a cell suspension, stained with microglia or astrocyte-specific fluorescent antibodies, and fractionated into astrocytic or microglial clean fractions. Cells were lysed and proteins processed for proteomic analysis. Brain outline based on Paxinos and Watson`s atlas. Created in BioRender. Kuter, K. (2026) https://BioRender.com/1cxstxv .

    Techniques Used: Injection, Suspension, Staining



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    Schematic representation of experimental model (A) and analysis workflow (B). Wistar Han rats were bilaterally injected with 6-OHDA (3 µg / 3 µl) into the medial forebrain bundle to induce selective degeneration of dopaminergic neurons and infused for 7 days with fluorocitrate (FC, 2 nmol/day, osmotic minipumps) to induce astrocyte death in the substantia nigra. Substantia nigra tissue was dissected and dissociated into a cell suspension, stained with microglia or astrocyte-specific fluorescent antibodies, and fractionated into astrocytic or microglial clean fractions. Cells were lysed and proteins processed for <t>proteomic</t> analysis. Brain outline based on Paxinos and Watson`s atlas. Created in BioRender. Kuter, K. (2026) https://BioRender.com/1cxstxv .
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    Schematic representation of experimental model (A) and analysis workflow (B). Wistar Han rats were bilaterally injected with 6-OHDA (3 µg / 3 µl) into the medial forebrain bundle to induce selective degeneration of dopaminergic neurons and infused for 7 days with fluorocitrate (FC, 2 nmol/day, osmotic minipumps) to induce astrocyte death in the substantia nigra. Substantia nigra tissue was dissected and dissociated into a cell suspension, stained with microglia or astrocyte-specific fluorescent antibodies, and fractionated into astrocytic or microglial clean fractions. Cells were lysed and proteins processed for <t>proteomic</t> analysis. Brain outline based on Paxinos and Watson`s atlas. Created in BioRender. Kuter, K. (2026) https://BioRender.com/1cxstxv .
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    Schematic representation of experimental model (A) and analysis workflow (B). Wistar Han rats were bilaterally injected with 6-OHDA (3 µg / 3 µl) into the medial forebrain bundle to induce selective degeneration of dopaminergic neurons and infused for 7 days with fluorocitrate (FC, 2 nmol/day, osmotic minipumps) to induce astrocyte death in the substantia nigra. Substantia nigra tissue was dissected and dissociated into a cell suspension, stained with microglia or astrocyte-specific fluorescent antibodies, and fractionated into astrocytic or microglial clean fractions. Cells were lysed and proteins processed for <t>proteomic</t> analysis. Brain outline based on Paxinos and Watson`s atlas. Created in BioRender. Kuter, K. (2026) https://BioRender.com/1cxstxv .
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    Site-Specific Photo-Crosslinking Strategy for Studying IFITM3-Interacting Proteins in Live Cells The amber suppression technology mediates site-specific incorporation of the diazirine-containing DiZPK into IFITM3, which enables in-cell photo-crosslinking with interacting proteins. The photo-crosslinked complexes were analyzed by western blot and identified by quantitative <t>proteomics</t> after IP.
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    Image Search Results


    Schematic representation of experimental model (A) and analysis workflow (B). Wistar Han rats were bilaterally injected with 6-OHDA (3 µg / 3 µl) into the medial forebrain bundle to induce selective degeneration of dopaminergic neurons and infused for 7 days with fluorocitrate (FC, 2 nmol/day, osmotic minipumps) to induce astrocyte death in the substantia nigra. Substantia nigra tissue was dissected and dissociated into a cell suspension, stained with microglia or astrocyte-specific fluorescent antibodies, and fractionated into astrocytic or microglial clean fractions. Cells were lysed and proteins processed for proteomic analysis. Brain outline based on Paxinos and Watson`s atlas. Created in BioRender. Kuter, K. (2026) https://BioRender.com/1cxstxv .

    Journal: Data in Brief

    Article Title: Glial cell-specific proteomic data from the substantia nigra of a rat 6-OHDA and fluorocitrate model of astrocyte death and microglial activation

    doi: 10.1016/j.dib.2026.112473

    Figure Lengend Snippet: Schematic representation of experimental model (A) and analysis workflow (B). Wistar Han rats were bilaterally injected with 6-OHDA (3 µg / 3 µl) into the medial forebrain bundle to induce selective degeneration of dopaminergic neurons and infused for 7 days with fluorocitrate (FC, 2 nmol/day, osmotic minipumps) to induce astrocyte death in the substantia nigra. Substantia nigra tissue was dissected and dissociated into a cell suspension, stained with microglia or astrocyte-specific fluorescent antibodies, and fractionated into astrocytic or microglial clean fractions. Cells were lysed and proteins processed for proteomic analysis. Brain outline based on Paxinos and Watson`s atlas. Created in BioRender. Kuter, K. (2026) https://BioRender.com/1cxstxv .

    Article Snippet: The dataset shows proteomic results (timsTOF Pro 2 (Bruker)) obtained using an originally developed method of adult rat brain isolation of astrocytes or microglia from the same sample.

    Techniques: Injection, Suspension, Staining

    Site-Specific Photo-Crosslinking Strategy for Studying IFITM3-Interacting Proteins in Live Cells The amber suppression technology mediates site-specific incorporation of the diazirine-containing DiZPK into IFITM3, which enables in-cell photo-crosslinking with interacting proteins. The photo-crosslinked complexes were analyzed by western blot and identified by quantitative proteomics after IP.

    Journal: Cell Chemical Biology

    Article Title: Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase

    doi: 10.1016/j.chembiol.2020.03.004

    Figure Lengend Snippet: Site-Specific Photo-Crosslinking Strategy for Studying IFITM3-Interacting Proteins in Live Cells The amber suppression technology mediates site-specific incorporation of the diazirine-containing DiZPK into IFITM3, which enables in-cell photo-crosslinking with interacting proteins. The photo-crosslinked complexes were analyzed by western blot and identified by quantitative proteomics after IP.

    Article Snippet: Proteomics database search results , This study; Mendeley Data , https://doi.org/10.17632/tds8by96gc.1.

    Techniques: Western Blot, Quantitative Proteomics

    Quantitative Proteomics Enable Identification of Photo-Crosslinked IFITM3-Interacting Proteins (A) Scheme for “forward” SILAC quantitative proteomic analysis of photo-crosslinked interaction partners of IFITM3. In a complementary “reverse” SILAC proteomic analysis, light cells were UV irradiated, while heavy cells were not. (B) Normalized SILAC ratios for forward and reverse SILAC proteomic analysis with DiZPK-modified IFITM3 at position 8. VCP, highly enriched in photo-crosslinking samples, is marked in red. Other identified proteins that were not enriched in photo-crosslinking samples are shown in black and represent non-covalent IFITM3-interacting proteins or non-specifically binding proteins. (C) Validation of IFITM3-VCP photo-crosslinking complex. HEK293T cells expressing AlkPK or DiZPK-modified HA-IFITM3 and myc-VCP were UV irradiated and subjected to anti-HA IP for western blot analysis. The red asterisk indicates co-immunoprecipitated VCP and the double red asterisks indicate photo-crosslinked IFITM3-VCP complex.

    Journal: Cell Chemical Biology

    Article Title: Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase

    doi: 10.1016/j.chembiol.2020.03.004

    Figure Lengend Snippet: Quantitative Proteomics Enable Identification of Photo-Crosslinked IFITM3-Interacting Proteins (A) Scheme for “forward” SILAC quantitative proteomic analysis of photo-crosslinked interaction partners of IFITM3. In a complementary “reverse” SILAC proteomic analysis, light cells were UV irradiated, while heavy cells were not. (B) Normalized SILAC ratios for forward and reverse SILAC proteomic analysis with DiZPK-modified IFITM3 at position 8. VCP, highly enriched in photo-crosslinking samples, is marked in red. Other identified proteins that were not enriched in photo-crosslinking samples are shown in black and represent non-covalent IFITM3-interacting proteins or non-specifically binding proteins. (C) Validation of IFITM3-VCP photo-crosslinking complex. HEK293T cells expressing AlkPK or DiZPK-modified HA-IFITM3 and myc-VCP were UV irradiated and subjected to anti-HA IP for western blot analysis. The red asterisk indicates co-immunoprecipitated VCP and the double red asterisks indicate photo-crosslinked IFITM3-VCP complex.

    Article Snippet: Proteomics database search results , This study; Mendeley Data , https://doi.org/10.17632/tds8by96gc.1.

    Techniques: Quantitative Proteomics, Multiplex sample analysis, Irradiation, Modification, Binding Assay, Biomarker Discovery, Expressing, Western Blot, Immunoprecipitation

    Journal: Cell Chemical Biology

    Article Title: Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase

    doi: 10.1016/j.chembiol.2020.03.004

    Figure Lengend Snippet:

    Article Snippet: Proteomics database search results , This study; Mendeley Data , https://doi.org/10.17632/tds8by96gc.1.

    Techniques: Virus, Recombinant, Protease Inhibitor, Multiplex sample analysis, Transfection, Western Blot, Antibody Labeling, BIA-KA, Mutagenesis, Control, Cloning, Plasmid Preparation, Software, Magnetic Beads